Filed by Bowne Pure Compliance

OMB Number: 3235-0058
Expires: April 30, 2009
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Washington, D.C. 20549
FORM 12b-25
(Check one):   o  Form 10-K o  Form 20-F o  Form 11-K þ  Form 10-Q o  Form 10-D o  Form N-SAR o  Form N-CSR
  For Period Ended:   June 30, 2007
    o   Transition Report on Form 10-K  
    o   Transition Report on Form 20-F  
    o   Transition Report on Form 11-K  
    o   Transition Report on Form 10-Q  
    o   Transition Report on Form N-SAR  
  For the Transition Period Ended:    

Read Instruction (on back page) Before Preparing Form. Please Print or Type.
Nothing in this form shall be construed to imply that the Commission has verified any information contained herein.
If the notification relates to a portion of the filing checked above, identify the Item(s) to which the notification relates:
Integra LifeSciences Holdings Corporation
Full Name of Registrant
Former Name if Applicable
311 Enterprise Drive
Address of Principal Executive Office (Street and Number)
Plainsboro, NJ 08536
City, State and Zip Code
PART II — RULES 12b-25(b) AND (c)
If the subject report could not be filed without unreasonable effort or expense and the registrant seeks relief pursuant to Rule 12b-25(b), the following should be completed. (Check box if appropriate)
    (a)   The reason described in reasonable detail in Part III of this form could not be eliminated without unreasonable effort or expense
    (b)   The subject annual report, semi-annual report, transition report on Form 10-K, Form 20-F, Form 11-K, Form N-SAR or Form N-CSR, or portion thereof, will be filed on or before the fifteenth calendar day following the prescribed due date; or the subject quarterly report or transition report on Form 10-Q or subject distribution report on Form 10-D, or portion thereof, will be filed on or before the fifth calendar day following the prescribed due date; and
      (c)   The accountant’s statement or other exhibit required by Rule 12b-25(c) has been attached if applicable.
State below in reasonable detail why Forms 10-K, 20-F, 11-K, 10-Q, 10-D, N-SAR, N-CSR, or the transition report or portion thereof, could not be filed within the prescribed time period.
Due to recent turnover in staff accounting personnel, the Registrant was unable, without unreasonable effort or expense, to file its Quarterly Report on Form 10-Q for the period ended June 30, 2007 with the Securities and Exchange Commission within the prescribed time period. In addition, key personnel were required to devote time and attention to the IsoTis transaction announced on August 7, 2007. In accordance with Rule 12b-25 under the Securities Exchange Act of 1934, as amended, the Registrant anticipates filing its Form 10-Q for the quarter ended June 30, 2007 no later than five calendar days following the prescribed due date.
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(Attach extra Sheets if Needed)
(1)   Name and telephone number of person to contact in regard to this notification
Maureen B. Bellantoni    (609)    275-0500 
  (Area Code)   (Telephone Number)
(2)   Have all other periodic reports required under Section 13 or 15(d) of the Securities Exchange Act of 1934 or Section 30 of the Investment Company Act of 1940 during the preceding 12 months or for such shorter period that the registrant was required to file such report(s) been filed? If answer is no, identify report(s).
    Yes þ     No o
(3)   Is it anticipated that any significant change in results of operations from the corresponding period for the last fiscal year will be reflected by the earnings statements to be included in the subject report or portion thereof?
    Yes þ     No o
    If so, attach an explanation of the anticipated change, both narratively and quantitatively, and, if appropriate, state the reasons why a reasonable estimate of the results cannot be made.
On August 7, 2007, the Registrant issued a press release announcing financial results for the quarter ended June 30, 2007. A copy of the press release is attached as Exhibit 99.1 to the Registrant’s Current Report on Form 8-K, dated August 7, 2007.

For the quarter ending June 30, 2007, the Registrant reported total revenues of $134.8 million, reflecting an increase of $34.6 million over the second quarter of 2006. The Registrant reported net income of $9.3 million, or $0.31 per diluted share, for the second quarter of 2007, compared to net income of $8.0 million, or $0.26 per diluted share, in the second quarter of 2006.
Integra LifeSciences Holdings Corporation 
(Name of Registrant as Specified in Charter)
has caused this notification to be signed on its behalf by the undersigned hereunto duly authorized.
  August 9, 2007   By   /s/ Maureen B. Bellantoni
          Maureen B. Bellantoni
          Executive Vice President and
Chief Financial Officer