SECURITIES AND EXCHANGE COMMISSION

                             WASHINGTON, D.C. 20549

                                 ---------------



                                    FORM 8-K

                                 CURRENT REPORT




     Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934

       Date of Report (Date of earliest event reported): December 31, 2005

                       LIGAND PHARMACEUTICALS INCORPORATED
             (Exact name of registrant as specified in its charter)

                                    DELAWARE
                 (State or other jurisdiction of incorporation)

                                    000-20720
                            (Commission File Number)

                           10275 SCIENCE CENTER DRIVE
                              SAN DIEGO, CALIFORNIA
                    (Address of principal executive offices)

                                 (858) 550-7500
              (Registrant's telephone number, including area code)

                                   77-0160744
                      (I.R.S. Employer Identification No.)

                                   92121-1117
                                   (Zip Code)









ITEM 1.01 ENTRY INTO A MATERIAL DEFINITIVE AGREEMENT


AMENDMENT TO 2005 DIRECTOR FEE OPTION GRANTS - 409A

            The American  Jobs Creation Act of 2004 imposed new taxes on certain
compensation arrangements with directors and officers by adding new section 409A
to the Internal  Revenue  Code.  The  Treasury  Department  subsequently  issued
guidance for the purpose of transitioning to the new law which, in part,  allows
certain  changes to  compensation  arrangements  prior to December 31, 2005 such
that the  arrangements  are not  subject to new  section  409A (the  "Transition
Relief").  On or about December 31, 2005, the Company entered into amendments to
certain options granted to its non-employee directors in 2005 under its Director
Fee Option Program (the "Program") pursuant to the Transition Relief.

         The Program is  implemented  under the 2002 Plan for each calendar year
until otherwise  determined by the  Compensation  Committee.  Under the Program,
each  non-employee  Board member may elect,  prior to the start of each calendar
year, to apply all or any portion of the annual fees  otherwise  payable in cash
for his or her period of  service on the Board for that year to the  acquisition
of a special discounted option grant. The option grant is a non-statutory option
under the federal tax laws and is automatically made on the first trading day in
January in the  calendar  year for which the director fee election is in effect.
The option has a maximum  term of 10 years  measured  from the grant date and an
exercise  price per share equal to  one-third  of the fair  market  value of the
option  shares on such  date.  The number of shares  subject  to each  option is
determined by dividing the amount of the annual fees applied to the  acquisition
of that option by  two-thirds of the fair market value per share of common stock
on the grant date. As a result,  the total spread on the option (the fair market
value of the option shares on the grant date less the aggregate  exercise  price
payable for those  shares) is equal to the portion of the annual fees applied to
the acquisition of the option. The dollar amount of the fee subject to the Board
member's election each year is equal to his or her annual retainer fee, plus the
number of regularly-scheduled Board meetings for that year multiplied by the per
Board meeting fee in effect for such year.

     Each 2005 grant  under the  Program  was amended to comply with the section
409A such that either:


     (A)  it will be automatically  exercised upon the first to occur of (1) the
          director's  death or disability,  (2) the director's  separation  from
          service  with the  Company,  within the meaning of Section 409A of the
          Code,  (3) a change  in the  ownership  or  effective  control  of the
          Company, or in the ownership of a substantial portion of the assets of
          the Company,  within the meaning of Section  409A of the Code,  or (4)
          the tenth anniversary of the date of grant; or 

     (B)  it may be  exercised  only on or  before  March 15,  2006 and,  if not
          exercised by that date, will be  automatically  exercised on March 15,
          2006.




The 2005 director fee option grants  subject to these  amendments  are set forth
below:




                         2005 DIRECTOR FEE OPTION GRANTS



                                             
                Name                            OPTION
                                                SHARES
                -------------------------------------------

                Henry F. Blissenbach            2,009
                Alexander D. Cross, Ph.D        1,841
                John Groom                      3,683
                Irving S. Johnson, Ph.D         1,841
                John W. Kozarich, Ph.D          3,683
                Carl C. Peck, M.D               1,841




AMENDMENT TO OUTSTANDING DIRECTOR OPTION GRANTS - SFAS No. 123R

In December 2004, the Financial  Accounting Standards Board issued SFAS No. 123R
(revised  2004),  SHARE-BASED  PAYMENT (SFAS 123R).  SFAS 123R replaced SFAS No.
123,  ACCOUNTING  FOR  STOCK-BASED   COMPENSATION  (SFAS  123),  and  superseded
Accounting  Principles  Board  Opinion No. 25,  ACCOUNTING  FOR STOCK  ISSUED TO
EMPLOYEES  (APB 25). In April 2005,  the SEC  approved a new rule that  requires
public  companies to apply SFAS 123R in their next fiscal year  beginning  after
June 15, 2005. As a result the Company  adopted SFAS 123R  beginning  January 1,
2006.
 

All options  previously  granted to  non-employee  directors and  outstanding on
December  31,  2005 had a "cash  settlement"  feature  in the event of a Hostile
Take-Over/Hostile  Tender  Offer,  as  defined in under the 2002 Plan and in the
option  agreements.  Under SFAS 123R, this "cash settlement"  feature would have
required  the Company to  reclassify  those  options as a liability  rather than
equity,  to revalue the options at fair value and to  recognize a  corresponding
expense and  reduction  in net income in 2006.  The Company  projected  that the
reduction in net income associated with the "cash settlement" feature would have
been  approximately  $4 million to $5 million based on the cumulative  change in
accounting for director options which were vested on January 1, 2006.

Accordingly the Company,  on December 31, 2005, entered into an amendment with
each of its non-employee  directors to remove the "cash  settlement"  feature in
each  outstanding  option  agreement in order to avoid the  reclassification  of
these options and the projected 2006 impact on the Company's financial results.






                                   SIGNATURES

         Pursuant to the  requirements  of the Securities  Exchange Act of 1934,
the  registrant  has  caused  this  report  to be  signed  on its  behalf by the
undersigned.


                           LIGAND PHARMACEUTICALS INCORPORATED




Date: January 6, 2006      By:      /s/  Warner R. Broaddus
                           Name:    Warner R. Broaddus
                           Title:   Vice President, General Counsel & Secretary