UNITED STATES
                        SECURITIES EXCHANGE COMMISSION
                            Washington, D.C. 20549

______________________________________________________________________________


                                 SCHEDULE 13G

                   Under the Securities Exchange Act of 1934
                               (Amendment No. 1)

                      LIGAND PHARMACEUTICALS INCORPORATED
                      -----------------------------------
                               (Name of Issuer)


                    Common Stock, $.001 par value per share
              ---------------------------------------------------
                        (Title of Class of Securities)


                                   53220K207
                         -----------------------------
                                (CUSIP Number)


                               December 31, 2005
                         -----------------------------
            (Date of Event which Requires Filing of this Statement)


Check  the  appropriate  box to  designate  the rule  pursuant  to which  this
Schedule is filed:

                              [   ]  Rule 13d-1(b)

                              [ X ]  Rule 13d-1(c)

                              [   ]  Rule 13d-1(d)

* The  remainder  of this  cover  page  shall be  filled  out for a  reporting
person's  initial  filing on this form with  respect to the  subject  class of
securities,  and for any subsequent  amendment  containing  information  which
would alter the disclosures provided in a prior cover page.

The  information  required  in the  remainder  of this cover page shall not be
deemed to be "filed" for the purpose of Section 18 of the Securities  Exchange
Act of 1934 ("Act") or otherwise subject to the liabilities of that section of
the Act but shall be subject to all other provisions of the Act (however,  see
the Notes).


                         Continued on following pages
                              Page 1 of 11 Pages
                             Exhibit Index: Page 9




                                 SCHEDULE 13G

CUSIP No.:   53220K207                                      Page 2 of 11 Pages
...............................................................................
1.    Names of Reporting Persons.

      I.R.S. Identification Nos. of above persons (entities only).


      GLENVIEW CAPITAL MANAGEMENT, LLC
...............................................................................
2.    Check the Appropriate Box if a Member of a Group

      (a) [ ]

      (b) [ ]
...............................................................................
3.    SEC Use Only
...............................................................................
4.    Citizenship or Place of Organization

      Delaware
...............................................................................
Number of       5.    Sole Voting Power           None
Shares        ................................................................
Beneficially    6.    Shared Voting Power         6,906,000
Owned by Each ................................................................
Reporting       7.    Sole Dispositive Power      None
Person With   ................................................................
                8.    Shared Dispositive Power    6,906,000
...............................................................................
9.    Aggregate Amount Beneficially Owned by Each Reporting Person

      6,906,000
...............................................................................
10.   Check if the Aggregate Amount in Row (9) Excludes Certain Shares
      (See Instructions)

      [  ]
...............................................................................
11.   Percent of Class Represented by Amount in Row (9)

      9.3% based on 74,131,283 shares outstanding as of December 15, 2004.
...............................................................................
12.   Type of Reporting Person:

      OO



                                 SCHEDULE 13G

CUSIP No.:   53220K207                                      Page 3 of 11 Pages
...............................................................................
1.    Names of Reporting Persons.

      I.R.S. Identification Nos. of above persons (entities only).


      GLENVIEW CAPITAL GP, LLC
...............................................................................
2.    Check the Appropriate Box if a Member of a Group

      (a) [ ]

      (b) [ ]
...............................................................................
3.    SEC Use Only
...............................................................................
4.    Citizenship or Place of Organization

      Delaware
...............................................................................
Number of       5.    Sole Voting Power           None
Shares        ................................................................
Beneficially    6.    Shared Voting Power         6,906,000
Owned by Each ................................................................
Reporting       7.    Sole Dispositive Power      None
Person With   ................................................................
                8.    Shared Dispositive Power    6,906,000
...............................................................................
9.    Aggregate Amount Beneficially Owned by Each Reporting Person

      6,906,000
...............................................................................
10.   Check if the Aggregate Amount in Row (9) Excludes Certain Shares
      (See Instructions)

      [  ]
...............................................................................
11.   Percent of Class Represented by Amount in Row (9)

      9.3% based on 74,131,283 shares outstanding as of December 15, 2004.
...............................................................................
12.   Type of Reporting Person:

      OO



                                 SCHEDULE 13G

CUSIP No.:   53220K207                                      Page 4 of 11 Pages
...............................................................................
1.    Names of Reporting Persons.

      I.R.S. Identification Nos. of above persons (entities only).


      GLENVIEW CAPITAL MASTER FUND, LTD.
...............................................................................
2.    Check the Appropriate Box if a Member of a Group

      (a) [ ]

      (b) [ ]
...............................................................................
3.    SEC Use Only
...............................................................................

4.    Citizenship or Place of Organization

      Cayman Islands, British West Indies
...............................................................................
Number of       5.    Sole Voting Power           None
Shares        ................................................................
Beneficially    6.    Shared Voting Power         3,980,843
Owned by Each ................................................................
Reporting       7.    Sole Dispositive Power      None
Person With   ................................................................
                8.    Shared Dispositive Power    3,980,843
...............................................................................
9.    Aggregate Amount Beneficially Owned by Each Reporting Person

      3,980,843
...............................................................................
10.   Check if the Aggregate Amount in Row (9) Excludes Certain Shares
      (See Instructions)

      [X]
...............................................................................
11.   Percent of Class Represented by Amount in Row (9)

      5.4% based on 74,131,283 shares outstanding as of December 15, 2004.
...............................................................................
12.   Type of Reporting Person:

      IA



                                 SCHEDULE 13G

CUSIP No.:   53220K207                                      Page 5 of 11 Pages
...............................................................................
1.    Names of Reporting Persons.

      I.R.S. Identification Nos. of above persons (entities only).


      LAWRENCE M. ROBBINS
...............................................................................
2.    Check the Appropriate Box if a Member of a Group

      (a) [ ]

      (b) [ ]
...............................................................................
3.    SEC Use Only
...............................................................................
4.    Citizenship or Place of Organization

      United States of America
...............................................................................
Number of       5.    Sole Voting Power           None
Shares        ................................................................
Beneficially    6.    Shared Voting Power         6,906,000
Owned by Each ................................................................
Reporting       7.    Sole Dispositive Power      None
Person With   ................................................................
                8.    Shared Dispositive Power    6,906,000
...............................................................................
9.    Aggregate Amount Beneficially Owned by Each Reporting Person

      6,906,000
...............................................................................
10.   Check if the Aggregate Amount in Row (9) Excludes Certain Shares
      (See Instructions)

      [  ]
...............................................................................
11.   Percent of Class Represented by Amount in Row (9)

      9.3% based on 74,131,283 shares outstanding as of December 15, 2004.
...............................................................................
12.   Type of Reporting Person:

      IA



                                                            Page 6 of 11 Pages

Item 1(a).      Name of Issuer:

                Ligand Pharmaceuticals Incorporated (the "Issuer")

Item 1(b).      Address of Issuer's Principal Executive Offices:

                10275 Science Center Drive, San Diego, CA 92121-1117.

Item 2(a).      Name of Person Filing

                This  Statement  is  filed on behalf of each of the  following
persons (collectively, the "Reporting Persons"):

                i)    Glenview  Capital  Management,  LLC ("Glenview   Capital
                      Management");

                ii)   Glenview Capital GP, LLC ("Glenview Capital GP");

                iii)  Glenview  Capital  Master  Fund, Ltd. ("Glenview Capital
                      Master Fund); and

                iv)   Lawrence M. Robbins ("Mr. Robbins").

                This  Statement relates to Shares (as defined herein) held for
the  accounts  of  Glenview  Capital   Partners,   L.P.,  a  Delaware  limited
partnership ("Glenview Capital Partners"),  Glenview  Institutional  Partners,
L.P., a Delaware limited partnership ("Glenview Institutional Partners"),  GCM
Little Arbor Master Fund, Ltd., a Cayman Islands exempted company ("GCM Little
Arbor Master Fund"), GCM Little Arbor Institutional Partners, L.P., a Delaware
limited  partnership  ("GCM Little  Arbor  Institutional  Partners"),  and GCM
Little Arbor Partners, L.P., a Delaware limited partnership ("GCM Little Arbor
Partners").

                Glenview  Capital  Management  serves as investment manager to
each of Glenview Capital Partners,  Glenview Institutional Partners,  Glenview
Capital   Master  Fund,  GCM  Little  Arbor  Master  Fund,  GCM  Little  Arbor
Institutional  Partners,  and GCM Little  Arbor  Partners.  In such  capacity,
Glenview Capital Management may be deemed to have voting and dispositive power
over the Shares held for the  accounts of each of Glenview  Capital  Partners,
Glenview  Institutional  Partners,  Glenview  Capital  Master Fund, GCM Little
Arbor Master Fund,  GCM Little Arbor  Institutional  Partners,  and GCM Little
Arbor Partners. Glenview Capital GP is the general partner of Glenview Capital
Partners,  Glenview  Institutional  Partners,  GCM Little Arbor  Institutional
Partners and GCM Little Arbor Partners. Glenview Capital GP also serves as the
sponsor of the  Glenview  Capital  Master Fund and the GCM Little Arbor Master
Fund. In such capacities, Glenview Capital GP may be deemed to have voting and
dispositive  power over the Shares  held for the  accounts of each of Glenview
Capital Partners,  Glenview  Institutional  Partners,  Glenview Capital Master
Fund, GCM Little Arbor Master Fund, GCM Little Arbor  Institutional  Partners,
and GCM Little Arbor Partners.  Mr. Robbins is the Chief Executive  Officer of
Glenview Capital Management and Glenview Capital GP.

Item 2(b).      Address of Principal Business Office or, if None, Residence

                The  address  of  the  principal  business  office  of each of
Glenview Capital Management,  Glenview Capital GP, and Mr. Robbins is 399 Park
Avenue,  Floor 39, New York,  New York  10022.  The  address of the  principal
business  office of  Glenview  Capital  Master Fund is Harbour  Centre,  North
Church Street,  P.O. Box 8966T,  George Town,  Grand Cayman,  Cayman  Islands,
British West Indies.



                                                            Page 7 of 11 Pages

Item 2(c).      Citizenship

                i)    Glenview   Capital  Management  is  a  Delaware  limited
                      liability company;

                ii)   Glenview  Capital  GP  is  a  Delaware limited liability
                      company;

                iii)  Glenview   Capital  Master  Fund  is  a  Cayman  Islands
                      exempted company; and

                iv)   Mr.  Robbins  is  a  citizen  of  the  United  States of
                      America.

Item 2(d).      Title of Class of Securities:

                Common Stock, $0.001 par value per share (the "Shares")

Item 2(e).      CUSIP Number:

                53220K207

Item 3.         If  This  Statement is Filed Pursuant to ss.ss.240.13d-1(b) or
                240.13d-2(b) or (c),Check Whether the Person Filing is a:

                This Item 3 is not applicable.

Item 4.         Ownership:

Item 4(a).      Amount Beneficially Owned:

                (i)   As  of  February  14,  2006,  each of  Glenview  Capital
Management,  Glenview  Capital  GP and Mr.  Robbins  may be  deemed  to be the
beneficial  owner of 6,906,000  Shares.  This amount  consists of: (A) 346,013
Shares held for the account of Glenview Capital Partners; (B) 3,980,843 Shares
held for the account of Glenview  Capital  Master Fund;  (C) 1,939,844  Shares
held for the account of Glenview  Institutional  Partners;  (D) 498,902 Shares
held for the account of GCM Little Arbor Master Fund,  (E) 131,856 Shares held
for the  account of GCM Little  Arbor  Institutional  Partners,  and (F) 8,542
Shares held for the account of GCM Little Arbor Partners.

                (ii) As of February 14, 2006, Glenview Capital Master Fund may
be deemed to be the beneficial owner of 3,980,843 Shares. This amount consists
of 3,980,843 Shares held for its account.

Item 4(b)       Percent of Class:

                (i) The  number of Shares of which  each of  Glenview  Capital
Management,  Glenview  Capital  GP and Mr.  Robbins  may be  deemed  to be the
beneficial owner constitutes  approximately 9.3% of the total number of Shares
outstanding  (based  upon  information  provided  by the  Issuer  in its  most
recently-filed  proxy statement,  there were  approximately  74,131,283 shares
outstanding as of December 15, 2004).

                (ii) The  number of Shares of which  Glenview  Capital  Master
Fund may be deemed to be the beneficial owner constitutes  approximately  5.4%
of the total number of Shares outstanding (based upon information  provided by
the  Issuer  in  its  most   recently-filed   proxy   statement,   there  were
approximately 74,131,283 shares outstanding as of December 15, 2004).




                                                            Page 8 of 11 Pages

Item 4(c)       Number of Shares of which such person has:

Glenview Capital Management, Glenview Capital GP, and Mr. Robbins:
------------------------------------------------------------------

(i)   Sole power to vote or direct the vote:                                 0

(ii)  Shared power to vote or direct the vote:                       6,906,000

(iii) Sole power to dispose or direct the disposition of:                    0

(iv)  Shared power to dispose or direct the disposition of:          6,906,000


Glenview Capital Master Fund:
-----------------------------

(i)   Sole power to vote or direct the vote:                                 0

(ii)  Shared power to vote or direct the vote:                       3,980,843

(iii) Sole power to dispose or direct the disposition of:                    0

(iv)  Shared power to dispose or direct the disposition of:          3,980,843


Item 5.         Ownership of Five Percent or Less of a Class:

                This Item 5 is not applicable

Item 6.         Ownership  of  More  than  Five  Percent on Behalf of Another
                Person:

                This Item 6 is not applicable

Item 7.         Identification  and  Classification  of  the Subsidiary Which
                Acquired the Security Being Reported on By the Parent Holding
                Company:

                See disclosure in Item 2 hereof.

Item 8.         Identification and Classification of Members of the Group:

                This Item 8 is not applicable.

Item 9.         Notice of Dissolution of Group:

                This Item 9 is not applicable.

Item 10.        Certification:

                By signing below each of the Reporting Persons certifies that,
to the best of their  knowledge and belief,  the securities  referred to above
were not  acquired  and are not held for the  purpose of or with the effect of
changing or  influencing  the control of the issuer of the securities and were
not acquired and are not held in connection  with or as a  participant  in any
transaction having that purpose or effect.




                                                            Page 9 of 11 Pages

                                   SIGNATURE

      After  reasonable  inquiry and to the best of my knowledge and belief, I
certify that the information set forth in this statement is true, complete and
correct.

Date: February 14, 2006              GLENVIEW CAPITAL MANAGEMENT, LLC


                                     By: /s/ Lawrence M. Robbins
                                         -----------------------------
                                     Name:   Lawrence M. Robbins
                                     Title:  Chief Executive Officer

Date: February 14, 2006              GLENVIEW CAPITAL GP, LLC


                                     By:  /s/ Lawrence M. Robbins
                                          ----------------------------
                                     Name:   Lawrence M. Robbins
                                     Title:  Chief Executive Officer

Date: February 14, 2006              GLENVIEW CAPITAL MASTER FUND, LTD.

                                     By: Glenview Capital Management, LLC
                                         As Investment Manager


                                     By:  /s/ Lawrence M. Robbins
                                          ----------------------------
                                     Name:   Lawrence M. Robbins
                                     Title:  Chief Executive Officer

Date: February 14, 2006              LAWRENCE M. ROBBINS


                                     /s/ Lawrence M. Robbins
                                     -----------------------




                                                           Page 10 of 11 Pages


                                 EXHIBIT INDEX


Ex.                                                                   Page No.
---                                                                   --------

B.    Joint Filing Agreement, dated February 14, 2006 by and among
      Glenview Capital Management, LLC, Glenview Capital GP, LLC,
      Glenview Capital Master Fund, Ltd. and Lawrence M.
      Robbins.....................................................          11





                                                           Page 11 of 11 Pages



                                   EXHIBIT B

                            JOINT FILING AGREEMENT

      The  undersigned  hereby  agree  that the  statement  on  Schedule  13G,
Amendment  No. 1 with  respect to the Common  Stock of Ligand  Pharmaceuticals
Incorporated  dated as of  February  14, 2006 is, and any  amendments  thereto
(including amendments on Schedule 13D) signed by each of the undersigned shall
be,  filed on  behalf of each of us  pursuant  to and in  accordance  with the
provisions  of Rule  13d-1(k)  under the  Securities  Exchange Act of 1934, as
amended.

Date: February 14, 2006              GLENVIEW CAPITAL MANAGEMENT, LLC


                                     By: /s/ Lawrence M. Robbins
                                         -----------------------------
                                     Name:   Lawrence M. Robbins
                                     Title:  Chief Executive Officer

Date: February 14, 2006              GLENVIEW CAPITAL GP, LLC


                                     By:  /s/ Lawrence M. Robbins
                                          ----------------------------
                                     Name:   Lawrence M. Robbins
                                     Title:  Chief Executive Officer

Date: February 14, 2006              GLENVIEW CAPITAL MASTER FUND, LTD.

                                     By:  Glenview Capital Management, LLC
                                          As Investment Manager


                                     By:  /s/ Lawrence M. Robbins
                                          ----------------------------
                                     Name:   Lawrence M. Robbins
                                     Title:  Chief Executive Officer

Date: February 14, 2006              LAWRENCE M. ROBBINS


                                     /s/ Lawrence M. Robbins
                                     ----------------------------