UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 4 STATEMENT OF CHANGES IN BENEFICIAL OWNERSHIP [ ] Check this box if no longer subject to Section 16. Form 4 or Form 5 obligations may continue. 1. Name and Address of Reporting Person(s) McCormick, Ann M 1600 Faraday Avenue Carlsbad, CA 92008 2. Issuer Name and Ticker or Trading Symbol Invitrogen Corporation (IVGN) 3. I.R.S. Identification Number of Reporting Person, if an entity (Voluntary) 4. Statement for Month/Day/Year 2/18/2003 5. If Amendment, Date of Original (Month/Day/Year) 6. Relationship of Reporting Person(s) to Issuer (Check all applicable) [ ] Director [ ] 10% Owner [X] Officer (give title below) [ ] Other (specify below) VP, Mfg Ops 7. Individual or Joint/Group Filing (Check Applicable Line) [X] Form filed by One Reporting Person [ ] Form filed by More than One Reporting Person Table I Non-Derivative Securities Acquired, Disposed of, or Beneficially Owned ------------------------------------------------------------------------------------------------------------------------------------ 1)Title of Security 2)Trans- 3.Trans- 4.Securities Acquired(A) 5)Amount of 6) 7)Nature of action action or Disposed of (D) Securities Indirect Date Code A Beneficially D Beneficial (Month/ or Owned at or Ownership Day/Year) Code V Amount D Price End of Month I ------------------------------------------------------------------------------------------------------------------------------------ Common Stock 10/31/02 J V 29 A $23.6980 D Direct Common Stock 01/31/03 J V 24 A $24.0125 D Direct Common Stock 02/18/03 S 5,000 D $30.0600 D Direct Common Stock 02/18/03 S 2,000 D $30.0400 D Direct Common Stock 02/18/03 S 1,500 D $30.1500 D Direct Common Stock 02/18/03 S 5,100 D $30.1100 D Direct Common Stock 02/18/03 S 3,400 D $30.1600 D Direct Common Stock 02/18/03 S 3,200 D $30.1400 D Direct Common Stock 02/18/03 S 4,800 D $30.2000 60,012 D Direct Table II (PART 1) Derivative Securities Acquired, Disposed of, or Beneficially Owned (Columns 1 through 6) ------------------------------------------------------------------------------------------------------------------------------------ 1)Title of Derivative 2)Conversion 3)Trans- 4)Trans- 5)Number of Derivative 6)Date Exercisable and Security or Exercise action action Securities Acquired (A) Expiration Date Price of Date Code or Disposed of (D) Derivative Security Code V A D Exercisable Expiration ------------------------------------------------------------------------------------------------------------------------------------ Incentive Stock Option (right $5.6000 05/28/03 05/28/08 to buy) Incentive Stock Option (right $45.6400 02/28/06 02/28/12 to buy) Incentive Stock Option (right $54.3750 01/04/05 01/04/10 to buy) Incentive Stock Option (right $60.0000 01/01/07 01/01/10 to buy) Non-Qualified Stock Option $34.5100 09/06/03 09/06/12 (right to buy) Non-Qualified Stock Option $45.6400 02/28/06 02/28/12 (right to buy) Non-Qualified Stock Option $54.3750 12/04/04 01/04/10 (right to buy) Incentive Stock Option (right $3.8000 11/06/02 11/06/07 to buy) Table II (PART 2) Derivative Securities Acquired, Disposed of, or Beneficially Owned (Columns 1,3 and 7 through 11) ------------------------------------------------------------------------------------------------------------------------------------ 1)Title of Derivative 3)Trans- 7)Title and Amount 8)Price 9)Number of 10) 11)Nature of Security action of Underlying of Deri- Derivative Indirect Date Securities vative Securities D Beneficial Amount or Security Beneficially or Ownership Number of Owned at I - Title Shares End of Month ------------------------------------------------------------------------------------------------------------------------------------ Incentive Stock Option (right Common Stock 8,000 8,000 D Direct to buy) Incentive Stock Option (right Common Stock 3,885 3,885 D Direct to buy) Incentive Stock Option (right Common Stock 8,368 8,368 D Direct to buy) Incentive Stock Option (right Common Stock 917 917 D Direct to buy) Non-Qualified Stock Option Common Stock 25,000 25,000 D Direct (right to buy) Non-Qualified Stock Option Common Stock 46,115 46,115 D Direct (right to buy) Non-Qualified Stock Option Common Stock 16,632 16,632 D Direct (right to buy) Incentive Stock Option (right Common Stock 3,000 3,000 D Direct to buy)Explanation of Responses: SIGNATURE OF REPORTING PERSON /S/ By: Cheri L. Manis For: Ann M McCormick DATE 02/18/03