Ownership Submission
FORM 4
Check this box if no longer subject to Section 16. Form 4 or Form 5 obligations may continue. See Instruction 1(b).
UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549

STATEMENT OF CHANGES IN BENEFICIAL OWNERSHIP OF SECURITIES

Filed pursuant to Section 16(a) of the Securities Exchange Act of 1934, Section 17(a) of the Public Utility Holding Company Act of 1935 or Section 30(h) of the Investment Company Act of 1940
OMB APPROVAL
OMB Number: 3235-0287
Expires: January 31, 2005
Estimated average burden hours per response... 0.5

(Print or Type Responses)
1. Name and Address of Reporting Person *
FLATLEY JAY T
   2. Issuer Name and Ticker or Trading Symbol
ILLUMINA INC [ILMN] 		5. Relationship of Reporting Person(s) to Issuer
(Check all applicable)
_____ Director _____ 10% Owner
__X__ Officer (give title below) _____ Other (specify below)
Chief Executive Officer
(Last)
(First)
(Middle)
5200 ILLUMINA WAY		 3. Date of Earliest Transaction (Month/Day/Year)
12/08/2015
(Street)

SAN DIEGO, CA 92122		 4. If Amendment, Date Original Filed(Month/Day/Year)
 6. Individual or Joint/Group Filing(Check Applicable Line)
_X_ Form filed by One Reporting Person
___ Form filed by More than One Reporting Person
(City)
(State)
(Zip)
Table I - Non-Derivative Securities Acquired, Disposed of, or Beneficially Owned
1.Title of Security
(Instr. 3)		 2. Transaction Date (Month/Day/Year) 2A. Deemed Execution Date, if any (Month/Day/Year) 3. Transaction Code
(Instr. 8)		 4. Securities Acquired (A) or Disposed of (D)
(Instr. 3, 4 and 5)		 5. Amount of Securities Beneficially Owned Following Reported Transaction(s)
(Instr. 3 and 4)		 6. Ownership Form: Direct (D) or Indirect (I)
(Instr. 4)		 7. Nature of Indirect Beneficial Ownership
(Instr. 4)
Code V Amount (A) or (D) Price
Common Stock 12/08/2015   A   9,630 (1) A $ 0 433,423 D  
Common Stock 12/08/2015   M   25,000 (2) A $ 27.97 458,423 D  
Common Stock 12/08/2015   S   6,384 (2) D $ 174.1046 (3) 452,039 D  
Common Stock 12/08/2015   S   2,851 (2) D $ 175.0868 (4) 449,188 D  
Common Stock 12/08/2015   S   463 (2) D $ 176.1943 (5) 448,725 D  
Common Stock 12/08/2015   S   4,068 (2) D $ 177.1334 (6) 444,657 D  
Common Stock 12/08/2015   S   3,270 (2) D $ 178.2802 (7) 441,387 D  
Common Stock 12/08/2015   S   1,764 (2) D $ 179.1966 (8) 439,623 D  
Common Stock 12/08/2015   S   6,200 (2) D $ 179.9947 (9) 433,423 D  
Common Stock               6,000 I By Daughters

Reminder: Report on a separate line for each class of securities beneficially owned directly or indirectly.
Persons who respond to the collection of information contained in this form are not required to respond unless the form displays a currently valid OMB control number. SEC 1474 (9-02)

Table II - Derivative Securities Acquired, Disposed of, or Beneficially Owned
(e.g., puts, calls, warrants, options, convertible securities)
1. Title of Derivative Security
(Instr. 3)		 2. Conversion or Exercise Price of Derivative Security 3. Transaction Date (Month/Day/Year) 3A. Deemed Execution Date, if any (Month/Day/Year) 4. Transaction Code
(Instr. 8)		 5. Number of Derivative Securities Acquired (A) or Disposed of (D)
(Instr. 3, 4, and 5)		 6. Date Exercisable and Expiration Date
(Month/Day/Year)		 7. Title and Amount of Underlying Securities
(Instr. 3 and 4)		 8. Price of Derivative Security
(Instr. 5)		 9. Number of Derivative Securities Beneficially Owned Following Reported Transaction(s)
(Instr. 4)		 10. Ownership Form of Derivative Security: Direct (D) or Indirect (I)
(Instr. 4)		 11. Nature of Indirect Beneficial Ownership
(Instr. 4)
Code V (A) (D) Date Exercisable Expiration Date Title Amount or Number of Shares
Performance Shares (10) 12/08/2015   A   28,888 (10)     (10) 12/30/2018 Common Stock 28,888 $ 0 28,888 D  
Non-qualified Stock Option (Right to Buy) $ 27.97 12/08/2015   M     25,000 (2) 03/01/2009 01/29/2019 Common Stock 25,000 $ 0 15,000 D  

Reporting Owners

Reporting Owner Name / Address Relationships
 Director  10% Owner  Officer  Other
FLATLEY JAY T
5200 ILLUMINA WAY
SAN DIEGO, CA 92122		       Chief Executive Officer  

Signatures

 By: Scott M. Davies for Jay T. Flatley   12/10/2015
**Signature of Reporting Person Date

Explanation of Responses:

* If the form is filed by more than one reporting person, see Instruction 4(b)(v).
** Intentional misstatements or omissions of facts constitute Federal Criminal Violations. See 18 U.S.C. 1001 and 15 U.S.C. 78ff(a).
(1) Grant of restricted stock units that vest as follows: 25% of the shares subject to the award become vested on November 5, 2016, November 5, 2017, November 5, 2018, and November 5, 2019, subject to awardee's continuing to be a service provider on such dates.
(2) The sale was made pursuant to a 10b5-1 plan.
(3) Weighted average sale price representing 6,384 shares sold ranging from $173.56 to $174.53 per share. Number of shares sold at each separate price will be made available to the SEC staff, the issuer, or a security holder of the issuer upon request.
(4) Weighted average sale price representing 2,851 shares sold ranging from $174.59 to $175.49 per share. Number of shares sold at each separate price will be made available to the SEC staff, the issuer, or a security holder of the issuer upon request.
(5) Weighted average sale price representing 463 shares sold ranging from $175.65 to $176.32 per share. Number of shares sold at each separate price will be made available to the SEC staff, the issuer, or a security holder of the issuer upon request.
(6) Weighted average sale price representing 4,068 shares sold ranging from $176.68 to $177.58 per share. Number of shares sold at each separate price will be made available to the SEC staff, the issuer, or a security holder of the issuer upon request.
(7) Weighted average sale price representing 3,270 shares sold ranging from $177.75 to $178.73 per share. Number of shares sold at each separate price will be made available to the SEC staff, the issuer, or a security holder of the issuer upon request.
(8) Weighted average sale price representing 1,764 shares sold ranging from $178.78 to $179.72 per share. Number of shares sold at each separate price will be made available to the SEC staff, the issuer, or a security holder of the issuer upon request.
(9) Weighted average sale price representing 6,200 shares sold ranging from $179.80 to $180.41 per share. Number of shares sold at each separate price will be made available to the SEC staff, the issuer, or a security holder of the issuer upon request.
(10) Each performance stock unit represents a contingent right to receive one share of common stock based on the Company's earnings per share for the fiscal year ending December 30, 2018. The number of shares issued will range from 0% to 150% of the amount specified above, based on the Company's actual earnings per share for the fiscal year ending December 30, 2018, relative to pre-defined objectives, subject to awardee's continuing to be a service provider on such dates.

Note: File three copies of this Form, one of which must be manually signed. If space is insufficient, see Instruction 6 for procedure.

Potential persons who are to respond to the collection of information contained in this form are not required to respond unless the form displays a currently valid OMB number.