Ownership Submission
FORM 3
 UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549

INITIAL STATEMENT OF BENEFICIAL OWNERSHIP OF SECURITIES

Filed pursuant to Section 16(a) of the Securities Exchange Act of 1934, Section 17(a) of the Public Utility Holding Company Act of 1935 or Section 30(h) of the Investment Company Act of 1940
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(Print or Type Responses)
1. Name and Address of Reporting Person *
  ORPIN TRISTAN
 2. Date of Event Requiring Statement (Month/Day/Year)
12/07/2015		 3. Issuer Name and Ticker or Trading Symbol
ILLUMINA INC [ILMN]
(Last)
(First)
(Middle)
5200 ILLUMINA WAY		 4. Relationship of Reporting Person(s) to Issuer
(Check all applicable)
_____ Director _____ 10% Owner
__X__ Officer (give title below) _____ Other (specify below)
EVP Clinical Genomics
 5. If Amendment, Date Original Filed(Month/Day/Year)
(Street)

SAN DIEGO, CA 92122		 6. Individual or Joint/Group Filing(Check Applicable Line)
_X_ Form filed by One Reporting Person
___ Form filed by More than One Reporting Person
(City)
(State)
(Zip)
Table I - Non-Derivative Securities Beneficially Owned
1.Title of Security
(Instr. 4)		 2. Amount of Securities Beneficially Owned
(Instr. 4)		 3. Ownership Form: Direct (D) or Indirect (I)
(Instr. 5)		 4. Nature of Indirect Beneficial Ownership
(Instr. 5)
Common Stock (1) (2) 99,427
D
 

Reminder: Report on a separate line for each class of securities beneficially owned directly or indirectly. SEC 1473 (7-02)
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Table II - Derivative Securities Beneficially Owned (e.g., puts, calls, warrants, options, convertible securities)
1. Title of Derivative Security
(Instr. 4)		 2. Date Exercisable and Expiration Date
(Month/Day/Year)		 3. Title and Amount of Securities Underlying Derivative Security
(Instr. 4)		 4. Conversion or Exercise Price of Derivative Security 5. Ownership Form of Derivative Security: Direct (D) or Indirect (I)
(Instr. 5)		 6. Nature of Indirect Beneficial Ownership
(Instr. 5)
Date Exercisable Expiration Date Title Amount or Number of Shares
Non-qualified Stock Option (Right to Buy) 02/27/2010(3) 01/27/2020 Common Stock 35,000 $ 37.04 D  
Non-qualified Stock Option (Right to Buy) 02/28/2011(3) 01/31/2021 Common Stock 5,000 $ 69.34 D  

Reporting Owners

Reporting Owner Name / Address Relationships
Director 10% Owner Officer Other
ORPIN TRISTAN
5200 ILLUMINA WAY
SAN DIEGO, CA 92122		       EVP Clinical Genomics  

Signatures

By: Scott M. Davies for Tristan B. Orpin 12/14/2015
**Signature of Reporting Person Date

Explanation of Responses:

* If the form is filed by more than one reporting person, see Instruction 5(b)(v).
** Intentional misstatements or omissions of facts constitute Federal Criminal Violations. See 18 U.S.C. 1001 and 15 U.S.C. 78ff(a).
(1) Includes 38,955 unvested performance stock units, which represent contingent right to receive one share of common stock based on the Company's earnings per share for fiscal years ending 1/3/16 (24,000 shares), 1/1/17 (8,438 shares), 12/31/17 (6,517 shares). Number of shares issued will range from 0% to 150% of the amount specified based on the Company's actual earnings per share for each fiscal year, relative to pre-defined objectives.
(2) Includes 7,716 unvested restricted stock units which vest as follows: 2,036 vesting 1/29/16, 1,312 vesting 3/8/16, 543 vesting 11/5/16, 2,036 vesting 1/29/17, 543 vesting 11/5/17, 703 vesting 1/29/18, 543 vesting 11/5/18.
(3) One forty-eighth (1/48) of the Shares subject to the Option become exercisable on the date indicated above, subject to Optionee's continuing to be a Service Provider on such date. An additional one-forty eighth (1/48) of the Shares subject to the Option shall become exercisable each full month therafter, subject to Optionee's continuing to be a Service Provider on such date.

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