Ownership Submission
FORM 3
 UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549

INITIAL STATEMENT OF BENEFICIAL OWNERSHIP OF SECURITIES

Filed pursuant to Section 16(a) of the Securities Exchange Act of 1934, Section 17(a) of the Public Utility Holding Company Act of 1935 or Section 30(h) of the Investment Company Act of 1940
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(Print or Type Responses)
1. Name and Address of Reporting Person *
  LABORATORY CORP OF AMERICA HOLDINGS
 2. Date of Event Requiring Statement (Month/Day/Year)
08/04/2009		 3. Issuer Name and Ticker or Trading Symbol
Monogram Biosciences, Inc. [[MGRM]]
(Last)
(First)
(Middle)
358 S MAIN ST		 4. Relationship of Reporting Person(s) to Issuer
(Check all applicable)
_____ Director __X__ 10% Owner
_____ Officer (give title below) _____ Other (specify below)
5. If Amendment, Date Original Filed(Month/Day/Year)
(Street)

BURLINGTON, NC 27215		 6. Individual or Joint/Group Filing(Check Applicable Line)
_X_ Form filed by One Reporting Person
___ Form filed by More than One Reporting Person
(City)
(State)
(Zip)
Table I - Non-Derivative Securities Beneficially Owned
1.Title of Security
(Instr. 4)		 2. Amount of Securities Beneficially Owned
(Instr. 4)		 3. Ownership Form: Direct (D) or Indirect (I)
(Instr. 5)		 4. Nature of Indirect Beneficial Ownership
(Instr. 5)
Common Stock 19,719,606
I
By Mastiff Acquisition Corp. (1)

Reminder: Report on a separate line for each class of securities beneficially owned directly or indirectly. SEC 1473 (7-02)
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Table II - Derivative Securities Beneficially Owned (e.g., puts, calls, warrants, options, convertible securities)
1. Title of Derivative Security
(Instr. 4)		 2. Date Exercisable and Expiration Date
(Month/Day/Year)		 3. Title and Amount of Securities Underlying Derivative Security
(Instr. 4)		 4. Conversion or Exercise Price of Derivative Security 5. Ownership Form of Derivative Security: Direct (D) or Indirect (I)
(Instr. 5)		 6. Nature of Indirect Beneficial Ownership
(Instr. 5)
Date Exercisable Expiration Date Title Amount or Number of Shares
Top-Up Option (right to buy) 08/04/2009   (2) Common Stock 10,623,670 $ 4.55 I By Mastiff Acquisition Corp. (3)

Reporting Owners

Reporting Owner Name / Address Relationships
Director 10% Owner Officer Other
LABORATORY CORP OF AMERICA HOLDINGS
358 S MAIN ST
BURLINGTON, NC 27215		     X    

Signatures

/s/ F. Samuel Eberts III, Authorized Person 08/06/2009
**Signature of Reporting Person Date

Explanation of Responses:

* If the form is filed by more than one reporting person, see Instruction 5(b)(v).
** Intentional misstatements or omissions of facts constitute Federal Criminal Violations. See 18 U.S.C. 1001 and 15 U.S.C. 78ff(a).
(1) These shares are owned directly by Mastiff Acquisition Corp., which is a wholly-owned subsidiary of Laboratory Corporation of America Holdings ("LabCorp"). LabCorp is the indirect beneficial owner of the reported securities.
(2) The Top-Up Option is exercisable, in whole but not in part, at any time prior to the earlier of (i) the Effective Time (as defined in the Agreement and Plan of Merger, dated June 22, 2009 among LabCorp, Mastiff Acquisition Corp., and the issuer (the "Merger Agreement"), filed as Exhibit 2.1 to the Form 8-K filed by the issuer with the Securities and Exchange Commission on June 24, 2009) and (ii) the termination of the Merger Agreement pursuant to Section 7.1 thereof.
(3) The right to exercise the Top-Up Option is held directly by Mastiff Acquisition Corp., which is a wholly-owned subsidisry of LabCorp. LabCorp is the indirect beneficial owner of the reported securities.

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