Can-Fite continues to build IP for its NASH drug candidate Namodenoson with patents granted and allowed in 37 countries

Can-Fite BioPharma Ltd. (NYSE American: CANF) (TASE: CFBI), a biotechnology company advancing a pipeline of proprietary small molecule drugs that address inflammatory, cancer and liver diseases, today announced that its patent titled "An A3 Adenosine Receptor Ligand For Use In Treating Ectopic Fat Accumulation" has been granted in Hong Kong and Mexico, and has received a notice of allowance in Japan. This patent addresses the use of the A3 Adenosine Receptor (A3AR) ligand, the target receptor for Can-Fite's drug platform technology, for ectopic fat accumulation particularly in fatty liver as manifested in non-alcoholic fatty liver disease (NAFLD) and non-alcoholic steatohepatitis (NASH), a market estimated to reach $35 billion by 2025.

Can-Fite’s Namodenoson completed a Phase IIa study in NASH which met its primary endpoint, and a Phase IIb study is underway.

“Our NASH-related patents are an important part of Can-Fite’s robust IP estate which spans 15 patent families. As we advance Namodenoson through clinical trials in NASH, which still lacks an FDA approved treatment, the IP strengthens our position with future distribution and development partners worldwide,” stated Can-Fite CEO Dr. Pnina Fishman.

Can-Fite has out-licensed Namodenoson for the indication of NASH in Eastern Europe, South Korea, and China. The Company has received approximately $20 million in non-dilutive upfront and milestone payments to date across all its indications.

About Can-Fite BioPharma Ltd.

Can-Fite BioPharma Ltd. (NYSE American: CANF) (TASE: CFBI) is an advanced clinical stage drug development Company with a platform technology that is designed to address multi-billion-dollar markets in the treatment of cancer, liver, inflammatory disease, and COVID-19. The Company's lead drug candidate, Piclidenoson, is currently in a Phase III trial for psoriasis and a Phase II study in the treatment of moderate COVID-19. Can-Fite's liver drug, Namodenoson, is headed into a Phase III trial for hepatocellular carcinoma (HCC), the most common form of liver cancer, and a Phase IIb trial for the treatment of non-alcoholic steatohepatitis (NASH). Namodenoson has been granted Orphan Drug Designation in the U.S. and Europe and Fast Track Designation as a second line treatment for HCC by the U.S. Food and Drug Administration. Namodenoson has also shown proof of concept to potentially treat other cancers including colon, prostate, and melanoma. CF602, the Company's third drug candidate, has shown efficacy in the treatment of erectile dysfunction. These drugs have an excellent safety profile with experience in over 1,500 patients in clinical studies to date. For more information please visit: www.can-fite.com.

Forward-Looking Statements

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